Diverse Fragment Collection
Domainex has assembled a unique collection of over 1,000 diverse fragments, including a set of sp3-rich fragments from our strategic partner SpiroChem. These are available for immediate screening.
- Multi-parameter scoring function used to select compounds
- Molecular fingerprints used and compared with ChEMBL fragments to ensure good coverage of bioactive space
- Access to SpiroChem fragments provides novel starting points
- All compounds soluble at 1mM in 1% DMSO
Fragments typically have: low molecular weight, a limited number of hydrogen bonding groups, a balance of polarity and lipophilicity and a limited number of rotatable bonds.