Diverse Fragment Collection

Domainex has assembled a unique collection of over 1,000 diverse fragments, including a set of sp3-rich fragments from our strategic partner SpiroChem. These are available for immediate screening.


  • Multi-parameter scoring function used to select compounds
  • Molecular fingerprints used and compared with ChEMBL fragments to ensure good coverage of bioactive space
  • Access to SpiroChem fragments provides novel starting points
  • All compounds soluble at 1mM in 1% DMSO

Fragments typically have: low molecular weight, a limited number of hydrogen bonding groups, a balance of polarity and lipophilicity and a limited number of rotatable bonds.

The Domainex fragment library adheres to these key principals